{"id":3980,"date":"2022-11-11T14:23:49","date_gmt":"2022-11-11T14:23:49","guid":{"rendered":"https:\/\/www.gaitbetter.com\/?p=3980"},"modified":"2025-07-30T08:27:17","modified_gmt":"2025-07-30T08:27:17","slug":"motor-cognitive-gait-training-for-ms-patients","status":"publish","type":"post","link":"https:\/\/www.gaitbetter.com\/it\/motor-cognitive-gait-training-for-ms-patients\/","title":{"rendered":"Treadmill training with virtual reality to enhance gait and cognitive function among people with multiple sclerosis: a randomized controlled trial"},"content":{"rendered":"
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Journal of Neurology. November 11th 2022 Online<\/a><\/h6>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Irina Galperin, Anat Mirelman, Tanja Shmitz-H\u00fcbsch, Katherine L. Hsieh, Keren Regev, Arnon Karni, Marina Brozgol, Pablo Cornejo Thumm, Sharon G. Lynch, Friedemann Paul, Hannes Devos, Jacob Sosnoff, Jeffrey M. Hausdorff<\/span><\/i><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Date: November 11, 2022<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Abstract<\/b><\/h4>

Background<\/b>\u00a0<\/p>

Cognitive and motor impairments impact the everyday functioning of people with multiple sclerosis (pwMS). This randomized controlled trial (RCT)\u00a0 evaluated the benefits of a combined virtual reality and motor\u2013cognitive training program on critical cognitive and motor symptoms as well as related outcomes in people with multiple sclerosis.\u00a0<\/p>

Methods<\/b>\u00a0<\/p>

In a single-blinded, two-arm RCT, 124 pwMS were randomized into a treadmill training with virtual reality (TT + VR) group or a treadmill training alone (TT) (active-control) group. For 6 weeks, each group received three training sessions per week. The primary outcomes were dual-tasking gait speed and cognitive processing speed (Symbol Digit Modalities Test, SDMT, score). Additional tests of cognitive function, mobility, and patient-reported questionnaires were secondary outcomes . Measurements were taken before, after, and three months after training.\u00a0<\/p>

Results<\/b>\u00a0<\/p>

Gait speed improved (p < 0.005) similarly by about 10 cm\/s in both groups. A clinically meaningful improvement of 4.4 points (95% CI 1.9\u20136.8, p = 0.001) in SDMT was shown in the TT + VR group (n = 53 analyzed per-protocol), compared to an improvement of only 0.8 points in the TT (n = 51 analyzed per-protocol) group (95% CI 0.9\u20132.5 points, p = 0.358) (group X time interaction effect p = 0.027). In addition, specific improvements were seen in depressive symptoms (lowered by 31%, p = 0.003), attention (17%, p < 0.001), and verbal fluency (11.6% increase, p = 0.002) in the TT + VR group.\u00a0<\/p>

Discussion<\/b>\u00a0<\/p>

These findings suggest that both\u00a0 TT + VR and TT improve usual and dual-task gait in people with multiple sclerosis. Furthermore, a VR based multi-modal approach positively impacts multiple aspects of cognitive function and mental health. This is more than seen after treadmill-training alone.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\tREAD THE PAPER<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"

JOURNAL OF NEUROLOGY<\/p>","protected":false},"author":7,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[32],"tags":[],"class_list":["post-3980","post","type-post","status-publish","format-standard","hentry","category-publications"],"_links":{"self":[{"href":"https:\/\/www.gaitbetter.com\/it\/wp-json\/wp\/v2\/posts\/3980","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.gaitbetter.com\/it\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.gaitbetter.com\/it\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.gaitbetter.com\/it\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/www.gaitbetter.com\/it\/wp-json\/wp\/v2\/comments?post=3980"}],"version-history":[{"count":5,"href":"https:\/\/www.gaitbetter.com\/it\/wp-json\/wp\/v2\/posts\/3980\/revisions"}],"predecessor-version":[{"id":69164,"href":"https:\/\/www.gaitbetter.com\/it\/wp-json\/wp\/v2\/posts\/3980\/revisions\/69164"}],"wp:attachment":[{"href":"https:\/\/www.gaitbetter.com\/it\/wp-json\/wp\/v2\/media?parent=3980"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.gaitbetter.com\/it\/wp-json\/wp\/v2\/categories?post=3980"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.gaitbetter.com\/it\/wp-json\/wp\/v2\/tags?post=3980"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}