{"id":2456,"date":"2017-10-24T11:10:11","date_gmt":"2017-10-24T11:10:11","guid":{"rendered":"https:\/\/www.gaitbetter.com\/?p=2456"},"modified":"2025-07-30T08:55:20","modified_gmt":"2025-07-30T08:55:20","slug":"neurology-disparate-effects-of-training-on-brain-activation-in-parkinson-disease","status":"publish","type":"post","link":"https:\/\/www.gaitbetter.com\/de\/neurology-disparate-effects-of-training-on-brain-activation-in-parkinson-disease\/","title":{"rendered":"Disparate effects of training on brain activation in Parkinson disease"},"content":{"rendered":"
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Neurology. 2017 Oct 24;89(17):1804-1810<\/a><\/h6>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Inbal Maidan, Keren Rosenberg-Katz, Yael Jacob, Nir Giladi, Jeffrey M Hausdorff, Anat Mirelman<\/span><\/i><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Date: October 24, 2017<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Overview<\/b><\/h4>

Comparing the effects of two forms of exercise, namely treadmill training combined with virtual reality (TT + VR) aimed at motor and cognitive aspects of safe ambulation and treadmill training alone (TT), on brain activation in patients with Parkinson disease (PD).<\/span><\/p>

Methods:<\/strong><\/p>

As part of a randomized controlled trial, patients were randomly assigned to 6 weeks of TT (n = 17, mean age 71.5 \u00b1 1.5 years, disease duration 11.6 \u00b1 1.6 years; 70% men) or TT + VR (n = 17, mean age 71.2 \u00b1 1.7 years, disease duration 7.9 \u00b1 1.4 years; 65% men). A validated fMRI imaging paradigm measured changes in neural activation pre- and post-training. Two virtual scenes were projected in the fMRI: (1) a path with no obstacles and (2) a path with virtual obstacles. The whole brain and the region of interest were analyzed.<\/span><\/p>

Results:<\/strong><\/p>

Brain activation patterns were similar between training arms before the interventions. Participants in the TT + VR arm had lower activation after training than the TT group arm in Brodmann area 10 and the inferior frontal gyrus (cluster level familywise error\u2013corrected [FWEcorr] p < 0.012), while the TT arm had lower activation than TT + VR in the cerebellum and middle temporal gyrus (cluster level FWEcorr p < 0.001). In the TT + VR arm, changes in fall frequency and brain activation were correlated.<\/span><\/p>

Conclusions:<\/strong><\/p>

Exercise modifies brain activation patterns in patients with Parkinson\u2019s disease in a mode-specific way. As a result of motor-cognitive training, the reliance on frontal regions was reduced, possibly reflecting a greater degree of brain efficiency.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\tREAD THE PAPER<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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The V-TIME academic research project has led to many of these papers, and is implemented commercially by GaitBetter.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"

NEUROLOGY<\/p>","protected":false},"author":7,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[32],"tags":[],"class_list":["post-2456","post","type-post","status-publish","format-standard","hentry","category-publications"],"_links":{"self":[{"href":"https:\/\/www.gaitbetter.com\/de\/wp-json\/wp\/v2\/posts\/2456","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.gaitbetter.com\/de\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.gaitbetter.com\/de\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.gaitbetter.com\/de\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/www.gaitbetter.com\/de\/wp-json\/wp\/v2\/comments?post=2456"}],"version-history":[{"count":5,"href":"https:\/\/www.gaitbetter.com\/de\/wp-json\/wp\/v2\/posts\/2456\/revisions"}],"predecessor-version":[{"id":69182,"href":"https:\/\/www.gaitbetter.com\/de\/wp-json\/wp\/v2\/posts\/2456\/revisions\/69182"}],"wp:attachment":[{"href":"https:\/\/www.gaitbetter.com\/de\/wp-json\/wp\/v2\/media?parent=2456"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.gaitbetter.com\/de\/wp-json\/wp\/v2\/categories?post=2456"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.gaitbetter.com\/de\/wp-json\/wp\/v2\/tags?post=2456"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}